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An Update on Equine Cushing’s Disease

The prevalence of PPID increases with age. Approximately 20% of equids (horses, donkeys, and mules) over 15 years and 30% of equids over 30 years of age are affected by the disease. Clinical signs can be obvious in advanced disease (long hair coat, poor shedding, laminitis, muscle wasting, immune compromise) but may be more subtle in its earlier stages (mild muscle atrophy, delayed healing, infertility, increased urination/drinking). Treatment of the disease involves life-long management with a medication (pergolide) and management changes but if managed appropriately, horses with PPID can have an excellent quality of life. 

Medicine, Wellness Crystal Lee Medicine, Wellness Crystal Lee

Understanding PPID

Many people have heard of PPID or Equine Cushing’s Disease, but it can be a difficult disease to fully understand. By reading this blog post you can better understand what PPID means, how PPID presents clinically, how we can diagnose PPID, and what we can do to manage our PPID patients.

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Medicine Crystal Lee Medicine Crystal Lee

Flor - Pituitary Pars Intermedia Dysfunction (PPID)

Pituitary pars intermedia dysfunction (PPID) is an endocrine disease that is thought to affect between 15-30% of aged horses. The most obvious clinical sign in more advanced cases is hypertrichosis (hair growth, abnormally long curly hair, and/or a failure to shed out normally in the summer). Other clinical signs can include increased drinking and urination, chronic infections, muscle wasting, weight loss, regional fat deposits, and an increased propensity to develop laminitis (founder). Because this disease occurs in older horses, it is often missed as the owner assumes that their horse isn't looking and feeling as well merely because they are getting older. The following is a report of one case in a horse used for competitive polo, written by her owner Connie:

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