With the exception of Strangles, all our commonly used equine vaccines are given intramuscularly. Rabies must be administered by a veterinarian, so it cannot be dispensed for owners to give, however the others can be dispensed. A note of caution, however—any vaccine can produce immediate, unpredictable adverse effects such as hives or anaphylaxis, which can be fatal if not treated promptly. If a veterinarian is administering a vaccination, they are required to have medications on hand that can address these concerns. If administering a vaccine yourself, monitor very closely for signs of these adverse effects and have a plan in place for prompt treatment.